Ummmm... first, don't look now, but ESPN already is active in a whole lot of non-conference scheduling.
Second, who loses?
If this year you'd had the choice of Louisiana Tech playing Southern Miss and Central Florida playing Tulane on a November Saturday, when you could have had, instead Louisiana Tech playing Central Florida... and some TV interest/advertising dollars in that, given some possible bowl implications... why would you choose otherwise? Heck, even a Southern Miss/Tulane match-up would be more interesting for that matter.
If you want more TV money, and most of us surely do, you have to be willing to do some things differently than you're used to doing.